There's something irresistibly comforting about a warm, bubbling casserole fresh out of the oven, and this Swiss Chicken Casserole is no exception. With tender chicken, a creamy sauce, and melted Swiss cheese layered over a bed of buttery stuffing, it’s the perfect dish to bring family and friends together around the table.

I first discovered this recipe during a holiday potluck years ago, and it’s been a staple in my kitchen ever since. Not only is it incredibly easy to make, but it’s also a crowd-pleaser that works for weeknight dinners or special occasions.

Why You’ll Love This Swiss Chicken Casserole

Get ready to fall in love with your new go-to comfort food. Swiss Chicken Casserole checks all the boxes for a delicious, hassle-free meal.

First off, this recipe is ridiculously easy to prepare. With only a handful of ingredients and minimal prep time, you can have it ready for the oven in just 15 minutes. It’s perfect for those evenings when you need a hearty meal without the fuss.

The flavors are a match made in heaven. The mild nuttiness of Swiss cheese, the creaminess of the sauce, and the savory stuffing topping come together to create a dish that’s both rich and satisfying.

It’s also incredibly versatile. Whether you want to swap out ingredients to suit your preferences or use up leftovers, this recipe adapts beautifully.

Best of all, it’s a one-dish wonder. No need to worry about multiple pots and pans—just assemble everything in a single casserole dish and let the oven do the work.

Ingredients Notes

The beauty of this casserole lies in its simple ingredients, each contributing to its signature flavor and texture. Here’s what you’ll need:

Chicken Breasts: Use boneless, skinless chicken breasts for the base of this dish. Slice them thinly or pound them to an even thickness for quicker cooking. You can also use leftover cooked chicken or rotisserie chicken for convenience.
Swiss Cheese: The mild, slightly nutty flavor of Swiss cheese is essential here. You can use pre-sliced cheese for easy layering, or grate a block for better melting.
Cream of Chicken Soup: This is the foundation of the creamy sauce. If you prefer a lighter option, use a low-fat version, or substitute with homemade cream sauce for a from-scratch twist.
Sour Cream: Adding a dollop of sour cream to the sauce enhances its creaminess and gives the casserole a slight tang.
Stuffing Mix: A boxed stuffing mix provides the buttery, herbed topping. Opt for a chicken-flavored stuffing to complement the dish, but any savory variety works well.
Butter: Melted butter is mixed with the stuffing to create a golden, crispy topping that contrasts beautifully with the creamy base.

Special equipment: A 9x13-inch casserole dish is the perfect size for this recipe.

How to Make Swiss Chicken Casserole

Creating this delicious casserole is as easy as layering a few simple ingredients. Here’s how to do it:

Prepare the Chicken: If using raw chicken breasts, slice them thinly or pound them to about ½ inch thickness. This ensures even cooking and prevents any undercooked spots. Preheat your oven to 350°F and lightly grease a 9x13-inch casserole dish.
Layer the Ingredients: Lay the chicken pieces in a single layer at the bottom of the prepared dish. Place slices of Swiss cheese over the chicken, covering it completely.
Make the Sauce: In a mixing bowl, whisk together cream of chicken soup and sour cream until smooth. Spread this creamy mixture evenly over the cheese layer, ensuring every bite will be rich and flavorful.
Add the Stuffing: In a separate bowl, combine the stuffing mix with melted butter. Stir until the stuffing is well-coated and slightly moistened, then sprinkle it over the top of the casserole.
Bake: Cover the dish with aluminum foil and bake in the preheated oven for 30 minutes. Remove the foil and bake for an additional 15 minutes, or until the stuffing is golden brown and the casserole is bubbling around the edges.

Total time: About 45 minutes from start to finish. You’ll be rewarded with a perfectly baked casserole that’s creamy, cheesy, and downright irresistible.

Storage Options

This casserole is perfect for making ahead or enjoying as leftovers. Here’s how to store it:

Refrigeration: Store any leftover casserole in an airtight container in the fridge for up to 3-4 days.
Freezing: Swiss Chicken Casserole freezes beautifully! Assemble the casserole as directed but don’t bake it. Cover tightly with plastic wrap and aluminum foil, and freeze for up to 2 months. When ready to bake, thaw overnight in the fridge and bake as directed.
Reheating: To reheat, cover the casserole with foil and warm in a 350°F oven until heated through. Individual portions can be microwaved for about 1-2 minutes.

Variations and Substitutions

The versatility of this recipe means you can easily customize it to suit your preferences or dietary needs. Here are a few ideas:

Swap the Protein: Don’t have chicken on hand? Try turkey, pork chops, or even ham slices as the base.
Go Gluten-Free: Use a gluten-free stuffing mix and ensure your cream of chicken soup is gluten-free to accommodate dietary restrictions.
Add Vegetables: Toss in steamed broccoli, green beans, or sautéed mushrooms for added nutrients and flavor.
Experiment with Cheese: While Swiss cheese is classic, you can mix things up with Gruyère, mozzarella, or even sharp cheddar for a different flavor profile.
Lighten It Up: Replace sour cream with plain Greek yogurt and opt for low-fat cheese and soup to reduce the calorie count without sacrificing taste.

Don’t be afraid to get creative—this recipe is forgiving and perfect for experimentation.

Now that you know all the tips and tricks, it’s time to grab your ingredients and get cooking. Whether you’re serving it as a comforting weeknight dinner or bringing it to a potluck, this Swiss Chicken Casserole is sure to be a hit. Enjoy!